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Randomized, Controlled Trials, Observational Studies, and the Hierarchy of Research Designs
A study published in the New England Jouranl of Medicine comparing the efficacy of randomized controlled trials to observational studies.
Conclusions The results of well-designed observational studies (with either a cohort or a case–control design) do not systematically overestimate the magnitude of the effects of treatment as compared with those in randomized, controlled trials on the same topic.
View the abstract: http://content.nejm.org/cgi/content/abstract/342/25/1887?ijkey=3d06a00da0a9c771752fa4318f9c2de26fcb09db&keytype2=tf_ipsecsha
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